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Intralesional Drug

An intralesional steroid injection is a treatment wherein a corticosteroid is injected directly into the treatment area or immediately below the skin.

This treatment can help with various skin issues. Such as:

  1. Keloid and Hypertrophic scars
  2. Neurodermatitis
  3. Localised psoriasis
  4. Acne cysts
  5. Localised inflammatory skin diseases

This treatment is beneficial because:

  • It doesn’t affect the other layers of the skin
  • Helps to decrease the possibility of  skin thinning

However, it is important to note that intralesional steroids should not be injected at an active skin infection.  In fact, they must not be used if there is a known triamcinolone allergy.

Moreover, sometimes, large doses of triamcinolone acetonide are used as an alternative to oral steroids. These are systemic steroids. However, they are not suitable for all patients. For instance, patients with:

  • Active tuberculosis
  • Active fungal infection
  • Extensive psoriasis
  • Active peptic ulcer disease
  • Uncontrolled diabetes
  • Severe hypertension
  • Severe depression or psychosis

How does the procedure work? 

  • Firstly, the treatment area is cleaned with an antiseptic solution or alcohol.
  • Secondly, dermatologists inject the intralesional steroid directly into the skin lesion with a fine needle.
  • In fact, the initial dose per injection site will vary depending on the lesion being treated.
  • It can be repeated every 4–8 weeks for a few months while the lesions are active.

Side effects

Firstly, you should tell your doctor if you have had an allergic reaction to a steroid medication in the past.

Moreover, the side effects and risks of intralesional triamcinolone can either be early and delayed effects.

Early effects tend to be self-limited. They include:

  • Pain
  • Bleeding
  • Bruising
  • Infection
  • Contact allergic dermatitis
  • Impaired wound healing
  • Sterile abscess

Moreover, delayed adverse effects include:

  1. Cutaneous and subcutaneous skin indentations or dimples around the injection sites. These can be permanent.
  2. White marks at the site of injection
  3. Post-inflammatory hyperpigmentation
  4. Broken red vessels at the site of injection (treatable)
  5. Localised excess hair growth (resolved eventually)
  6. Localised steroid acne (generally improves once the steroid has been stopped)

Moreover, allergic reactions are very rare and are dose-independent. In fact, they may include local or generalised urticaria and in more severe cases, life-threatening allergic reactions.

However, there are rare situations in which some people may face potentially serious conditions such as:

  1. Congestive heart failure
  2. Decreased glucose tolerance
  3. Cushing syndrome
  4. Hirsutism
  5. Diabetes mellitus
  6. Menstrual irregularities
  7. Neurologic/psychiatric symptoms
  8. Glaucoma
  9. Cataracts

Intralesional Drug


An intralesional steroid injection is a treatment wherein a corticosteroid is injected directly into the treatment area or immediately below the skin.

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